aggregated alphasynuclein activates microglia a process

Defining activation states of microglia in human brain ...

aggregated/phosphorylated alpha-synuclein accumulated into pathological inclusions [4]. These diseases are distinctive on account of the degenerative changes occurring in different brain regions; however, one common feature is the appearance of "activated" microglia within brain regions showing degenerative changes.

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T cell-microglial dialogue in Parkinson's disease and ...

Neuroinflammation is a pathological hallmark in Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), and is characterized by activated microglia and infiltrating T cells at sites of neuronal injury. In PD and ALS, neurons do not die alone; neuronal injury is non-cell-autonomous and depends on a well-orchestrated dialogue in which neuronally secreted misfolded proteins activate ...

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The role of Galectin-3 in α-synuclein-induced microglial ...

Microglial activation by α-synuclein and inhibition by galectin-3 inhibitor. We measured iNOS expression by western blot in microglial cells after 12 h incubation with α-synuclein monomers (A) and α-synuclein aggregates (B) using different concentrations, 5 μm, 10 μm and 20 μm. iNOS was significantly up regulated with both protein preparations of α-synuclein. α-synuclein aggregates (B ...

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Does immunotherapy need therapy? – The Science of Parkinson's

Firstly, they demonstrated that the clustered (or aggregated) form of this mutant alpha synuclein was activating the NLRP3 inflammasome, by exposing the microglia cells directly to the aggregated alpha synuclein protein. When they did this, the NLRP3 inflammasome became activated and the microglia began releasing pro-inflammatory cytokines.

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Cerebral sterile inflammation in neurodegenerative ...

Zhang W, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005; 19 :533–42. CAS PubMed Google Scholar

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Functions of Intracellular Alpha-Synuclein in Microglia ...

Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson's disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions. Although the activity of the protein has been extensively studied in neurons, the protein is also expressed in other cell types including immune cells and glia.

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"Alpha-Synuclein Aggregates Activate the Nlrp3 ...

The presynaptic protein α-synuclein is the primary constituent of LBs and has been documented to play a major role in the pathogenesis of synucleinopathies. Recently, aggregated α-synuclein has been implicated in prompting microglia-mediated inflammation, a process associated with the progression of neuronal death in neurodegenerative disorders.

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Synuclein activates microglia in a model of Parkinson's ...

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease FASEB J., 19 ( 2005 ), pp. 533 - 542 CrossRef View Record in Scopus Google Scholar

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Experimental Neurobiology

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J (2005) Aggregated alphasynuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 19:533-542.

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Inflammation and α-Synuclein's Prion-like Behavior in ...

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J (2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 19:533–542. PubMed CAS Article Google Scholar 38.

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CXCL12 is involved in α-synuclein-triggered ...

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19(6):533–42. CAS PubMed Article PubMed Central Google Scholar 24.

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Immunotherapy in Parkinson's Disease: Micromanaging Alpha ...

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML 2005 Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's disease FASEB J 19 6 533 542 63 Lee H-J, Suk J-E, Bae E-J, Lee S-J 2008 Clearance and deposition of extracellular α-synuclein aggregates in microglia Biochem Biophys Res Commun 372 3 ...

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CORE

(2005). Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. Faseb J (1995). AH: Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease. (2006).

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Inflammatory Responses to Monomeric and Aggregated α ...

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19 533–542. 10.1096/fj.04-2751com [ PubMed ] [ CrossRef ] [ Google Scholar ]

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Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades ...

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005;19: 533–42. pmid:15791003 . View Article PubMed/NCBI Google Scholar 14.

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Autoantibodies to alpha‐synuclein in inherited Parkinson's ...

Aggregated α-synuclein can trigger the activation of microglia; however, its capacity to induce production of specific autoantibodies (AAb) has not been assessed. In this study, we examined the presence of AAb against synuclein family members in the peripheral blood serum of PD patients and control individuals.

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microRNA-155 Regulates Alpha-Synuclein-Induced ...

(2005) Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 19 : 533 – 542, doi: 10.1096/fj.04-2751com, pmid: 15791003 . OpenUrl Abstract / FREE Full Text

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Aggregated alpha-synuclein activates microglia: a process ...

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

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Inflammatory Responses to Monomeric and Aggregated α ...

To investigate whether different forms of α-synuclein (α-syn) proteins can induce inflammation and activate the NLRP3 inflammasome, we stimulated with monomeric or aggregated α-syn peripheral blood mononuclear cells of Parkinson disease (PD) patients and age- and -matched healthy controls (HC). ASC-speck formation, i.e., the intracellular generation of functionally active …

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Role of Oxidative Stress in Parkinson's Disease

Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005; 19:533–542. [Google Scholar]

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Alpha-Synuclein Aggregates Activate the Nlrp3 …

inflammasome in response to aggregated α-synuclein in human microglia-like cells. We report that aggregated α-synuclein induces vesicle rupture in THP-1 cells that is sensed as a 'danger signal' resulting in the assembly of the NLRP3 inflammasome, activation of the inflammatory caspase-1, and the release of proinflammatory cytokines.

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Aggregated α‐synuclein activates microglia: a process ...

Aggregated α-synuclein activates microglia: a process leading to disease progression in Parkinson's disease Wei Zhang, Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA

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Microglia as modulators of exosomal alpha-synuclein ...

Zhang, W. et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19, 533–542 (2005). CAS Article Google Scholar

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Alpha-synuclein: from secretion to dysfunction and death ...

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005; 19 : 533–542. CAS Article PubMed Google Scholar

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[PDF] Neuron-released oligomeric α-synuclein is an ...

Abnormal aggregation of α-synuclein and sustained microglial activation are important contributors to the pathogenic processes of Parkinson's disease. However, the relationship between disease-associated protein aggregation and microglia-mediated neuroinflammation remains unknown. Here, using a combination of in silico, in vitro and in vivo approaches, we show that extracellular α-synuclein ...

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The role of natural killer cells in Parkinson's disease ...

Zhang, W. et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 19, …

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Microglial phagocytosis is enhanced by monomeric alpha ...

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhang W, Zhou Y, Hong JS, Zhang J. FASEB J, 19(6):533-542, 01 Apr 2005 Cited by: 598 articles | PMID: 15791003

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(PDF) Kv1.3 inhibition attenuates neuroinflammation ...

In experiments where cultured neonatal cultured neonatal microglia are stimulated with mouse microglia from wild-type and KV1.3−/- oligomeric amyloid-β (AβO) or α-synuclein [7,8], mice were stimulated with aggregate α-synuclein two proteins that are misfolded and aggregated in (αSynAgg), which activates microglia through bind Alzheimer ...

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Alpha-synuclein activates BV2 microglia dependent on its ...

Thus, alpha-synuclein may directly activate microglia, leading to increased production of key pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β), which in turn modulates the disease progression. The distinct alpha-synuclein species, which mediates the activation of microglia, is not well defined.

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Frontiers | Molecular Signatures of Neuroinflammation ...

22. Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, et al. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. (2005) 19:533–42. doi: 10.1096/fj.04-2751com. PubMed …

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